Strategies in Light

Feb 10th, 2010

Feb 12th, 2010

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Duke University engineers have developed a new type of microscope that uses a bowl studded with LED lights of various colors and lighting schemes produced by machine learning.

Microscope uses machine learning to optimize illumination settings

The microscope adapts its lighting angles, colors, and patterns while teaching itself the optimal settings needed to complete a given diagnostic task.

Methods of extracting features from label-free immune cell analysis are shown: Multivariate label-free data, composed of both morphological and spectral parameters, are used to identify high-level features at the single-cell level such as cellular type, response to drugs, as well as response differences between specimens.

Label-free multimodal imaging system distinguishes between cell types

The label-free multimodal imaging platform enables the study of cell cultures noninvasively without the need of any contrast agent.

Shown is a representation of the tapered optical fiber able to detect optical signals from different neurons simultaneously.

Tapered optical probe helps detect light in the brain

The new method allows the simultaneous collection of signals from various brain regions through the use of a tapered optical probe.

Fluorescent gel is applied to the mouth of a vampire bat in a rural area near Lima, Peru, to test the potential effectiveness of a 'spreadable' rabies vaccine. The bright red gel causes bat hair follicles to fluoresce under the microscope, so that researchers can track the spread of the biomarker through the bat population.

Fluorescent gel used in vampire bats could be effective rabies control

The fluorescent gel was applied to wild vampire bats at three colonies in Peru, where it simulated the bat-to-bat spread of an orotopical rabies vaccine.

Researchers used a new endoscopic OCT system to visualize variances in pig cartilage thickness; the image shows a sketch of a femur and processed OCT images with thin regions shown in dark red and thicker regions more yellow and white (scale bar = 250 µm).

Endoscopic OCT system could have use in minimally invasive joint surgery

The work is promising for bringing OCT imaging to new surgical and medical applications.

Endeavor Business Media acquires Informa’s Industry & Infrastructure Intelligence and Auto Aftermarket media brands

This latest acquisition continues to expand Endeavor’s position as one of the largest B2B companies.

An illustration representing Deep-Z, an artificial intelligence-based framework that can digitally refocus a 2D fluorescence microscope image (at bottom) to produce 3D slices (at left).

Deep learning converts 2D fluorescence microscopy images into 3D

Using a deep learning approach, researchers improved upon fluorescence microscopy to turn 2D images into stacks of virtual 3D slices showing activity inside organisms.

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Nominations open for 2019-2020 Cancer Community Awards

The Cancer Community (C2) Awards recognize individuals and organizations who have created positive change in cancer care.

Cytek Biosciences continues to expand their global footprint and has opened new offices in Tokyo and Amsterdam to better engage with and support customers; here, the O2 Lab Building at the Amsterdam UMC is shown.

Cytek Biosciences opens offices in Japan, The Netherlands

The company's flow cytometry systems have uses in clinical research fields such as immunology and immunotherapy.

Researchers induced engineered pancreatic beta cells to secrete insulin when exposed to blue light; insulin is shown here as a space filling atomic model.

Engineered cells responsive to light shown to enhance insulin production

The light-switchable cells are designed to compensate for the lower insulin production or reduced insulin response found in diabetic individuals.

Brolis Sensor Technology physicists at work at the company’s facilities.

Laser-based sensor could replace invasive blood analysis methods

The broadband laser-based sensor is able to remotely sense the concentration level of main critical blood constituents without drawing any blood.

UC Santa Cruz engineers Ahsan Habib (left) and Ali Yanik have developed ultrasensitive nanoscale optical probes to monitor the bioelectric activity of neurons and other electrogenic cells.

Optical nanoprobes could have use in monitoring neural activity

The nanoprobes could show how neural circuits function at an unprecedented scale by monitoring large numbers of individual neurons simultaneously.

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Fluorescent particles in the blood may help diagnose, monitor brain cancer

An imaging agent to improve surgeries for brain cancer by making tumor cells fluorescent has the potential to also help doctors safely diagnose the disease and monitor its response to treatment.

Visible light can activate an iridium (large purple ball) catalyst, which has a special coating (gray balls) which homes in on coenzyme NADH (red/gray/purple balls at bottom) in cancer cells and removes an electron from it, so destroying them by cutting off a vital energy source and generating a toxic form of oxygen (in the blue bubble).

Novel compound for phototherapy kills vital energy source for cancer cells

The phototherapy technique could lead to another tool for clinicians to use in the fight against cancer, and potentially even vaccinate patients against future cancers.