Bristol, UK-- Scientists from the Bristol Institute of Technology, University of the West of England, Bristol have developed a 3D test for malignant melanoma that can identify problems not easily spotted in a standard, two-dimensional view of the pattern on the skin. During the last 30 years, incidence rates have increased more than any other cancers in the UK. Successful treatment relies on early cancer diagnosis, so developing an automated scanning method that avoids the need to take biopsies is high on the research agenda.
Conventionally, a group of 2D skin measurements, the asymmetry, border, color and diameter (ABCD) rules are commonly used to distinguish between malignancy and benign skin growths, but diagnostic accuracy is not convincing.
Now, Lyndon Smith and colleagues at the Machine Vision Laboratory at the Bristol Institute of Technology have collaborated with Robert Warr of the Department of Plastic Surgery, at North Bristol NHS Trust, to develop a computer-assisted diagnosis system that could improve outcomes significantly. The system could quickly and automatically reveal changes in the 3D surface texture of skin that occur in malignant melanoma.
The team used a handheld, six-light stereo device connected to a laptop computer to scan the skin's surface. This device produces a 3D model of the skin texture patterns. The information is then analyzed by the laptop, which compares it with patterns recorded from known cases of melanoma, used to "train" the software.
Preliminary studies on a sample set including 12 malignant melanomas and 34 benign lesions have given 91.7% sensitivity and 76.4% specificity from analysis of the 3D skin surface normals, the team says, which is more accurate than the results obtained from 2D pattern recognition.
Based on these results, a simple and non-invasive 3D test could improve the accuracy of diagnosis and save lives, but also avoid unnecessary surgery and treatment in people with benign conditions.
Full bibliographic information is available at "A computer assisted diagnosis system for malignant melanoma using 3D skin surface texture features and artificial neural network," Int. J. Modelling, Identification and Control, 2010, 9, 370-381;