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Recognizing that current diagnostic tools are not sufficiently fast or sensitive to detect properties such as compressibility and viscoelasticity in infected cells, the research team designed their sensor by combining two optical sensing technologies, flow cytometry and mechanical sensing. The optofluidic device, explains doctoral candidate and first author Kewen Han, optically detects the mechanical perturbations created by individual microparticles flowing through the fluidic channel at very high speed.
|A glass fluid meniscus inside the optofluidic resonator carries particles through for optical detection at extremely high speeds. (Photo: University of Illinois)|
Han, along with Gaurav Bahl, an assistant professor of mechanical science and engineering at the University of Illinois, and colleagues tested their optofluidic resonator, measuring the density and compressibility of particles as small as 660 nm as they "whizzed" by the sensor.
Full details of the work appear in the journal Optica; for more information, please visit http://dx.doi.org/10.1364/OPTICA.3.000585.