Clinical system for cellular skin imaging

The MPTflex tomography system by JenLab GmbH (Jena, Germany) is designed to enable in vivo optical biopsies of human skin with subcellular spatial resolution. It aims to assist melanoma detection, diagnosis of dermatological disorders, tissue engineering, drug monitoring, and stem cell research among other applications. The CE-marked system is based on ultrafast multiphoton excitation of biomolecules such as NAD(P)H, flavins, porphyrins, elastin, and melanin.

The MPTflex tomography system by JenLab GmbH (Jena, Germany), successor to the company's DermaInspect system, is designed to enable in vivosubcellular spatial resolution. It aims to assist melanoma detection, diagnosis of dermatological disorders, tissue engineering, drug monitoring, and stem cell research among other applications.

The CE-marked system is based on ultrafast multiphoton excitation of biomolecules such as NAD(P)H, flavins, porphyrins, elastin, and melanin. The extracellular matrix element collagen can be identified by its second harmonic generation (SHG); a fast PMT detector module enables recording of autofluorescence and SHG signals with single-photon sensitivity.

MPTflex includes a compact, turnkey tunable femtosecond near infrared (NIR) laser, near infrared optics, a beam-scanning module with galvoscanners, piezo-driven optics, and a control unit including software for 3D image processing. An additional module for two-photon in-vivo FLIM is available. A flexible arm makes it easy to access many areas of the body while enabling the patient to remain comfortably positioned.

For more information see JenLab's website, www.jenlab.de.

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original press release from JenLab

MPTflex : New flexible Multiphoton Tomograph for clinical use
Jenlab GmbH (Germany) presents the new MPTflex at Laser World of Photonics 2009 Booth B1.356 in Munich.

JenLab introduces the new Multiphoton Tomograph MPTflex, as a unique tool for in vivo optical biopsies ofhuman skin with subcellular spatial resolution. Due to the new flexible arm, many positions of the human body can be easily reached for measurement.
The MPTflex is a CE- marked medical system based on femtosecond multiphoton excitation of biomolecules like NAD(P)H, flavins, porphyrins, elastin, and melanin. The extracellular matrix element collagen can be identified by its second harmonic generation (SHG). Autofluorescence and SHG signals are recorded by fast highly sensitive PMT detectors with single photon sensitivity.

The system consists of a compact, turn-key tunable femtosecond near infrared (NIR) laser, an articulated arm with near infrared optics, beam- scanning module with galvoscanners and piezo -driven optics, a fastPMT detector module as well as a control unit including JenLab Image software for 3D processing. An additional module for two-photon in-vivo FLIM can be provided.

The MPTflex is a powerful tool for:

+ Melanoma detection

+ Diagnostics of dermatological disorders

+ Tissue engineering

+ Cosmetic research, Skin Aging

+ In situ drug monitoring/ Intratissue imaging of pharmaceutical components

+ animal research studies/ stem cell research

+ detection of fluorescent proteins

The company JenLab GmbH was co-founded by Prof. Dr. Karsten Koenig in 1999 as a spin-off from the University in Jena (Germany). The product portfolio of JenLab includes a wide field of scientific equipment and supplementary products for optical nanotechnologies based on femtosecond lasers, particularly for applications in biotechnology, cell biology and medicine.

Customers have deployed JenLab products for applications in multiphoton tomography of skin cancer, micro- and nano-surgery, refractive ocular surgery as well as in nanoprocessing of semiconductors, glass, metals and polymers.

Jenlab GmbH
Schillerstr. 1
D-07745 Jena
Germany
Phone: (+)49 - 36 41 47 05 01
Fax: (+)49 - 36 41 47 05 43
E-Mail: info@jenlab.de
Web: www.jenlab.de

Posted by Barbara G. Goode, barbarag@pennwell.com, for BioOptics World.

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