Cancer Detection: Laser Doppler records bloodflow to enable early melanoma detection

A laser Doppler system able to detect the subtle differences in blood flow beneath the skin has allowed researchers—at Pisa University (Italy) and Lancaster University (England)—to distinguish between malignant melanoma and noncancerous moles.1 The noninvasive technique aims to speed tissue assessment and spare patients painful biopsies.

Noninvasive laser Doppler scanning of vasculature beneath moles has enabled detection of markers indicating melanoma.

"Skin malignant melanoma is a particularly aggressive cancer associated with quick blood vessel growth," said Prof. Marco Rossi of Pisa University, where 55 patients agreed to have their atypical moles scanned for about 30 minutes while the laser Doppler system recorded complex interactions in the subdermal blood vessels.

Then, Lancaster physicists analyzed fluctuations in recorded signals. "We used our knowledge of blood flow dynamics to pick up on markers which were consistently different in the blood vessels supplying malignant moles and those beneath normal skin," said Prof. Aneta Stefanovska of Lancaster University.

While American reviewers emphasize that further research is needed, and the system would need to overcome hurdles to be adopted, the results are promising: The test identified melanoma in all cases where it was present, and produced less than 10% false positives.

1. G. Lancaster et al., Sci. Rep., 5, 12825 (2015); doi:10.1038/srep12825.

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.

Microscope detects one million-plus biomarkers for sepsis in 30 minutes

A microscope has the potential to simultaneously detect more than one million biomarkers for sepsis at the point of care.

Photoacoustic imaging quantifies elasticity

Biomedical engineers in the US have developed a form of photoacoustic imaging that can quantify the elasticity of human tissue.

Flow cytometry analyzes cell population to predict cancer immunotherapy response

Flow cytometry helped find that the amount of white blood cells in melanoma tumors can predict response to a cancer therapy.

BLOGS

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...

CONNECT WITH US

            

Twitter- BioOptics World