SPATIALLY OFFSET RAMAN SPECTROSCOPY: Spectroscopic bone scanning yields more helpful data

X-ray-based diagnostics, by far the most widely used techniques for diagnosing bone disorders and diseases, are largely blind to the protein component of bone. But proteins determine important mechanical properties of bone, and changes in proteins have been associated with a number of bone diseases. Now, British researchers have demonstrated the use of spatially offset Raman spectroscopy (SORS) to detect a known compositional abnormality in the bones of a patient suffering from the genetic bone disorder osteogenesis imperfecta ("brittle bone disease").1 The work confirms the principle that bone diseases in living patients can be detected noninvasively, and points the way to larger studies that focus on osteoporosis and other chronic debilitating bone diseases.

The SORS method involves shining a laser through the skin to analyze the underlying chemistry of the bone, and can reveal differences between healthy and diseased bone. The research team includes scientists from University College London (UCL; London, England), the Science and Technology Facilities Council (STFC; Swindon, Wiltshire, England), and the Royal National Orthopaedic Hospital (RNOH; also in London). The custom-built SORS instrument was developed by Cobalt Light Systems (Abingdon, Oxfordshire, England).

According to Allen Goodship of UCL's Institute of Orthopaedics and Musculoskeletal Science, who led the research, the SORS method could become a routine tool that doctors can use during an annual check-up. This would allow physicians to advise patients on lifestyle changes that could slow the progress of the disease. With regular screening, SORS could monitor effects directly, he said.

1. K. Buckley et al., IBMS BoneKEy, 11, 602 (2014); doi:10.1038/bonekey.2014.97.

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

Optical sensor could assist with needle placement for epidurals, other procedures

A newly developed optical sensor can be embedded into an epidural needle, helping to guide the needle to the correct location.  

Spectroscopy: Raman spectroscopy advances for biomedical applications

Raman spectroscopy offers unique analytical capabilities applicable to a wide array of life science applications.

Multispectral method is noninvasive for imaging tissue oxygenation

A new multispectral approach for imaging tissue oxygenation could eliminate the need for surgical intervention.

Raman spectroscopy can help study blood stored in plastic blood bags

Raman spectroscopy can help study blood stored in plastic blood bags

Raman spectroscopy can monitor biochemical changes and inter-donor variability in stored red blood cell units.

BLOGS

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...

CONNECT WITH US

            

Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS