FLUORESCENCE/BIOMEDICAL IMAGING: Long-glowing phosphor promises in-vivo imaging applications

In-vivo bioimaging is one of the applications promised by a new near-infrared (NIR) phosphor that glows for up to two weeks after a one-minute exposure to sunlight or even indoor fluorescent lighting. Unlike glow-in-the-dark materials for the visible region, which are relatively common, persistent IR phosphors have been difficult to develop. Researchers at the University of Georgia (Athens, GA) have used their new phosphor as the basis for nanoparticles that bind to cancer cells, and foresee other biomedical applications as well.

Ceramic discs containing an important innovation—a persistent near-IR phosphor—demonstrate the power of the material for biomedical imaging applications
Ceramic discs containing an important innovation—a persistent near-IR phosphor—demonstrate the power of the material for biomedical imaging applications. (Image courtesy of Zhengwei Pan, University of Georgia)

The scientists spent three years developing the material in order to extend the usual time of emission from a few milliseconds to multiple weeks—and are continuing to tweak it in an effort to further performance. While the trivalent chromium ion used in the emitter normally glows for just a few milliseconds, the new material’s chemical structure creates a labyrinth of traps that capture and store energy. As the stored energy is thermally released back to the chromium ions at room temperature, the compound persistently emits NIR light. The phosphors emit strongly between 650 and 1000 nm; peak wavelength depends on the exact composition.

1. Z. Pan, Y.Y Lu, and F. Liu, Nat. Mat., 11, 58–63 (2012).

More BioOptics World Current Issue Articles
More BioOptics World Archives Issue Articles

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

New bioimaging technique offers clear view of nervous system

Scientists at Ludwig-Maximilians University have developed a technique for turning the body of a deceased rodent entirely transparent, revealing the central nervous system in unprecedented clarity....

Fluorescent jellyfish proteins light up unconventional laser

Safer lasers to map your cells could soon be in the offing -- all thanks to the humble jellyfish. Conventional lasers, like the pointer you might use to entertain your cat, produce light by emittin...

Fluorescence microscopy helps provide new insight into how cancer cells metastasize

By using fluorescence microscopy, scientists have discovered an alternate theory on how some cancer cells metastasize.

In vivo imaging method visualizes bone-resorbing cell function in real time

In vivo imaging can visualize sites where osteoclasts (bone-resorbing cells) were in the process of resorbing bone.

BLOGS

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...

CONNECT WITH US

            

Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS