SERS-based microfluidic chip distinguishes bacteria

Engineers at Taiwan's National Cheng Kung University have created an on-chip method for sorting and identifying bacteria.1 The surface-enhanced Raman spectroscopy (SERS)-based technique uses roughened glass slides patterned with gold electrodes, which the researchers used to create microchannels for sorting, trapping and identifying the bacteria. Proteins or other chemical components on the surface of bacteria become attached to the craggy gold zone; when excited, these components cause representative peaks at different wavelengths, creating spectral "fingerprints." Although some species of bacteria could show very similar signatures because the components on their surfaces are almost the same, bacteria from different genera are distinguishable using the technique.

By optimizing conditions such as the flow rate, applied voltage, and frequency, it is conceivable that the same approach could be used to sort different species of fungi, on the basis of their different electrical or physical properties. Thus, a portable device could enable preliminary screening for pathogenic targets in bacteria-infected blood, and in raw milk, for example.

1. I.F. Cheng et al., Biomicrofluidics 4: 034104 (2010)

More BioOptics World Current Issue Articles
More BioOptics World Archives Issue Articles

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

FDA authorizes emergency use of Zika virus molecular detection assay

The xMAP MultiFLEX Zika RNA assay combines optofluidics and digital signal processing to detect Zika virus in vitro.

Merz acquires laser tattoo removal device maker ON Light Sciences

Merz North America has acquired ON Light Sciences, which develops technologies to enhance laser-based dermatology procedures.

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.

Laser therapy extracts rare tumor that grew human hair, skin in boy's skull

About four years ago, a tumor comprised of human skin, hair, bone and cartilage was fast-growing inside a Ramsey, MN, 10-year-old youth's brain.

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS