PDT proves effective for early-stage oral cancers

Researchers at the Henry Ford Health System (Detroit, MI) have concluded a study that finds photodynamic laser therapy (PDT) effective for treating early-stage (Tis-T2N0M0) squamous cell carcinomas of the oral cavity and oropharynx. The approach they tested uses PHOTOFRIN (porfimer sodium) as a catalyst. The study involved 30 patients with early-stage cancer who were deemed not suitable for standard therapies or who had failed conventional therapy.

Each patient received an injection with PHOTOFRIN (dose 2.0 mg/kg) on an outpatient basis. Patients were treated in the operating room 48–60 hours later under general anesthesia with photoactivation using a 630 nm diode laser. The laser light was delivered via a microlens fiber for a surface treatment at a dose of 50–100 J/cm2 or via a 1.0 cm cylindrical diffusing fiber at a dose of 50–100 J/cm for interstitial technique.

Click to Enlarge

Following treatment, more than 80% of the patients (24) achieved complete remission, and the remaining 20% (6) saw partial remission for up to 26 months. Of the 24 patients who achieved a complete response, 11 remained free of disease at two years.

The work is described by V.G. Schweitzer and M.L. Somers in Lasers in Surgery and Medicine, 42:1-8, 2010.

More Brand Name Current Issue Articles
More Brand Name Archives Issue Articles

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

'Lab on a stick' test optically and rapidly detects antibiotic resistance

A point-of-care test, based on the dipstick method, can rapidly detect bacterial resistance to antibiotics in urine.

Merz acquires laser tattoo removal device maker ON Light Sciences

Merz North America has acquired ON Light Sciences, which develops technologies to enhance laser-based dermatology procedures.

New bioimaging technique offers clear view of nervous system

Scientists at Ludwig-Maximilians University have developed a technique for turning the body of a deceased rodent entirely transparent, revealing the central nervous system in unprecedented clarity....

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.


Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS