Sensor pairing two optical methods shows promise for high-speed disease detection

Scientists at the University of Illinois (Champaign, IL) have developed a highly sensitive sensor that combines two optical methods, with the goal of enabling new high-speed disease detection.

Related: Advances in optical biodetection

Recognizing that current diagnostic tools are not sufficiently fast or sensitive to detect properties such as compressibility and viscoelasticity in infected cells, the research team designed their sensor by combining two optical sensing technologies, flow cytometry and mechanical sensing. The optofluidic device, explains doctoral candidate and first author Kewen Han, optically detects the mechanical perturbations created by individual microparticles flowing through the fluidic channel at very high speed.

A glass fluid meniscus inside the optofluidic resonator carries particles through for optical detection at extremely high speeds. (Photo: University of Illinois)

Han, along with Gaurav Bahl, an assistant professor of mechanical science and engineering at the University of Illinois, and colleagues tested their optofluidic resonator, measuring the density and compressibility of particles as small as 660 nm as they "whizzed" by the sensor.

Full details of the work appear in the journal Optica; for more information, please visit

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

'Lab on a stick' test optically and rapidly detects antibiotic resistance

A point-of-care test, based on the dipstick method, can rapidly detect bacterial resistance to antibiotics in urine.

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.

Microscope detects one million-plus biomarkers for sepsis in 30 minutes

A microscope has the potential to simultaneously detect more than one million biomarkers for sepsis at the point of care.

Photoacoustic imaging quantifies elasticity

Biomedical engineers in the US have developed a form of photoacoustic imaging that can quantify the elasticity of human tissue.

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World