Profusa tissue-integrated optical biosensor monitors key body biochemicals in real time

Profusa (San Francisco, CA) has introduced its injectable Lumee optical biosensor technology at the Pioneers Festival, held May 24-25, 2016, in Vienna, Austria. Injectable biosensors that become one with the body's tissue may one day replace the clinical lab for making body chemistry continuously accessible for improved personal well-being in health and disease.

Related: The many approaches and applications of biosensing
 
Ben Hwang, Ph.D., Profusa's chairman and CEO, showcased the company's tissue-integrated biosensors for long-term, continuous tracking of body chemistry in a talk at the Pioneers Festival, explaining how the capability to provide a continuous stream of live data could have the power to revolutionize the relationship we have with our bodies and transform the entire healthcare ecosystem—from individuals to care providers and payers.

The biosensors will have applications for consumer health and wellness, as well as the management of chronic diseases such as peripheral artery disease (PAD), diabetes, and chronic obstructive pulmonary disease (COPD). With grant support by the Defense Advanced Research Project Agency (DARPA; Arlington County, VA), the National Institutes of Health (NIH; Bethesda, MD), and other funding agencies, Profusa's technology and novel bioengineering approach overcomes the effects of the largest hurdle in long-term use of biosensors in the body: the foreign body response. Placed under the skin with a specially designed injector, each tiny biosensor is a flexible fiber, 3- to 5-mm-long and approximately 500 µm in diameter. Rather than being isolated from the body, the biosensors work fully integrated within the body's tissue—without any metal device or electronics—overcoming the effects of the foreign body response.

Each biosensor is comprised of a bioengineered "smart hydrogel" (similar to contact lens material) forming a porous, tissue-integrating scaffold that induces capillary and cellular in-growth from surrounding tissue. The smart gel is linked to a fluorescent light-emitting molecule that continuously signals the presence of a body chemical such as oxygen, glucose, or other biomarker.

Adhered to the skin's surface or held by hand, a separate optical reader is used to read the fluorescent signal from the embedded biosensor. The reader sends excitation signals through the skin to the biosensor, which then emits light proportional to the concentration of molecules of interest. The data can be relayed to a smartphone for an encrypted personal record and historical tracking. Data can be shared securely via HIPAA-compliant digital networks with healthcare providers.

Profusa's first medical product, the Lumee Oxygen Sensing System, is a single-biomarker sensor designed to measure dissolved oxygen in the tissue. The system is being commercialized as long-term monitoring technology that guides therapeutic action and measures tissue oxygen levels during the treatment and healing process for PAD. Pending CE Mark, the system is slated to be available in Europe in 2016 for use by vascular surgeons and wound-healing specialists.

For more information, please visit www.profusa.com.

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

FDA authorizes emergency use of Zika virus molecular detection assay

The xMAP MultiFLEX Zika RNA assay combines optofluidics and digital signal processing to detect Zika virus in vitro.

'Lab on a stick' test optically and rapidly detects antibiotic resistance

A point-of-care test, based on the dipstick method, can rapidly detect bacterial resistance to antibiotics in urine.

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.

Microscope detects one million-plus biomarkers for sepsis in 30 minutes

A microscope has the potential to simultaneously detect more than one million biomarkers for sepsis at the point of care.

BLOGS

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...

CONNECT WITH US

            

Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS