Portable chemiluminescence biosensor detects analyte down to a few nanograms

Anitoa Systems (Menlo Park, CA) has applied its low-cost, portable CMOS chemiluminescence biosensor with a chemiluminescence immunoassay (CLIA). The combination approach is able to detect as low as a few nanograms-per-millliter of analyte (such as protein macromolecules) in a sample for use in clinical diagnostics, as well as in food safety and environmental monitoring.

Related: Infectious disease control with portable CMOS-based diagnostics

A key component of the company's portable chemiluminescence reader is its proprietary ULS24 CMOS biosensor chip. Endowed with extreme low-light sensitivity, it forms a single-chip chemiluminescence imaging device. The device also eliminates the need for a multi-sites scanning mechanism commonly used by most chemiluminescence readers when performing real-time imaging of multiple immunoassay reaction sites. At a 5 × 5 mm footprint and 30 mW power comsumption, the biosensor is has particular utility in point-of-care diagnostics.

Released commercially in September 2014, the biosensor has the needed sensitivity to substitute bulky, expensive photomultiplier tubes (PMTs) and cooled CCDs in a wide range of medical and scientific instruments. Its ultra-low light sensitivity (3e-6 lux) is crucial for achieving good signal-to-noise ratio (SNR) in imaging molecular interactions based on fluorescence or chemiluminescence signaling principles.

Immunoassays are important for detecting macromolecules in a sample (such as blood) using an antibody as probes. It has been used widely in diagnostics (infectious diseases, heart diseases), food safety, pharmaceutical analysis, and environmental monitoring. Based on the chemiluminescence signaling principle, chemiluminescence-based immunoassays provide orders-of-magnitude higher sensitivity and dynamic range than traditional color absorbance-based immunoassays (e.g., ELISA).

For more information, please visit www.anitoa.com.


Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

New bioimaging technique offers clear view of nervous system

Scientists at Ludwig-Maximilians University have developed a technique for turning the body of a deceased rodent entirely transparent, revealing the central nervous system in unprecedented clarity....

Fluorescent jellyfish proteins light up unconventional laser

Safer lasers to map your cells could soon be in the offing -- all thanks to the humble jellyfish. Conventional lasers, like the pointer you might use to entertain your cat, produce light by emittin...

Microscope detects one million-plus biomarkers for sepsis in 30 minutes

A microscope has the potential to simultaneously detect more than one million biomarkers for sepsis at the point of care.

Eye test that pairs two in vivo imaging methods may detect Parkinson's earlier

A low-cost, noninvasive eye test pairs two in vivo imaging methods to help detect Parkinson's before clinical symptoms appear.


Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World