Fully implantable device allows for wireless optogenetics

A team of researchers at Stanford University (California) has developed a miniature device that pairs optogenetics (using light to control the activity of the brain) with a new technique for wirelessly powering implanted devices. The device dramatically expands the scope of research that can be carried out through optogenetics to include experiments involving mice in enclosed spaces or interacting freely with other animals. What's more, it can be assembled and reconfigured for different uses in a lab, and the design of the power source is publicly available.

Related: Noninvasive optogenetics potentially promising for human applications

Traditionally, optogenetics has required a fiber-optic cable attached to a mouse's head to deliver light and control nerves. With this somewhat-restrictive headgear, mice can move in an open cage but cannot navigate an enclosed space or burrow into a pile of sleeping cage-mates the way an unencumbered mouse could. Also, before an experiment a scientist has to handle the mouse to attach the cable, stressing the mouse and possibly altering the outcome of the experiment.

These restrictions limit what can be learned through optogenetics. People have investigated a range of scientific questions including how to relieve tremors in Parkinson's disease, the function of neurons that convey pain, and possible treatments for stroke. However, addressing issues with a social component like depression or anxiety or that involve mazes and other types of complex movement is more challenging when the mouse is tethered.

This mouse's own body transmits energy to an implantable device that delivers light to stimulate leg nerves in a Stanford optogenetics project
This mouse's own body transmits energy to an implantable device that delivers light to stimulate leg nerves in a Stanford optogenetics project.

Ada Poon, an assistant professor of electrical engineering at Stanford who led the work, had an idea to use a mouse's own body to transfer radio frequency (RF) energy that was just the right wavelength to resonate in a mouse. She and Yuji Tanabe, a research associate in her lab, worked to build a chamber to amplify and store RF energy. They then overlaid a grid on top of the chamber with holes that were smaller than the wavelength of the energy contained within, which trapped the energy inside the chamber. Because the wavelength is the exact wavelength that resonates in mice, the mouse releases the energy from the chamber into its body, where it is captured by a 2 mm coil in the device. Wherever the mouse moves, its body comes in contact with the energy, drawing it in and powering the device. Elsewhere, the energy stays tidily contained. In this way, the mouse becomes its own localizing device for power delivery.

Implantable, wireless-powered devices produce light to stimulate nerves of the brain, spinal cord, or limbs in mice
Implantable, wireless-powered devices produce light to stimulate nerves of the brain, spinal cord, or limbs in mice.

This novel way of delivering power is what allowed the research team to create such a small device. The device  is small enough to be implanted under the skin and may be able to trigger a signal in muscles or some organs, which were previously not accessible to optogenetics.

The researchers say the device and the novel powering mechanism open the door to a range of new experiments to better understand and treat mental health disorders, movement disorders, and diseases of the internal organs. They have a Stanford Bio-X grant to explore and possibly develop new treatments for chronic pain.

Full details of the work appear in the journal Nature Methods; for more information, please visit http://dx.doi.org/10.1038/nmeth.3536.

Follow us on Twitter, 'like' us on Facebook, connect with us on Google+, and join our group on LinkedIn

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

FDA authorizes emergency use of Zika virus molecular detection assay

The xMAP MultiFLEX Zika RNA assay combines optofluidics and digital signal processing to detect Zika virus in vitro.

'Lab on a stick' test optically and rapidly detects antibiotic resistance

A point-of-care test, based on the dipstick method, can rapidly detect bacterial resistance to antibiotics in urine.

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.

Microscope detects one million-plus biomarkers for sepsis in 30 minutes

A microscope has the potential to simultaneously detect more than one million biomarkers for sepsis at the point of care.


Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS