LED Medical Diagnostics, BC Cancer Agency, and Genome BC sign agreement to develop oral cancer test

LED Medical Diagnostics (Burnaby, BC, Canada) has signed an agreement with the BC Cancer Agency and, in turn, Genome British Columbia (Genome BC) to create and commercialize a progression-risk assessment test for oral cancer. The test, the first of its kind for oral cancer, is based on a quantifiable genetic phenomenon known as loss of heterozygosity (LOH).

Related: Study supports tissue fluorescence visualization technology for oral cancer detection

The technology, which performs tissue fluorescence visualization, could help clinicians distinguish between high- and low-risk oral precancers, explains Peter Whitehead, LED Medical Diagnostics'  founder and director. "Until recently, a major barrier to oral cancer prevention has been the lack of validated risk predictors for oral premalignant lesions," he adds.  "In other words, there has been no way, until now, to know whether or not an oral lesion is likely to convert into cancer. This test, which measures specific genetic changes that have been shown to predict aggressive tumour growth, has the potential to lower oral cancer morbidity and mortality rates."

Oral cancer's reputation as a killer is based on statistical reality: the disease is commonly detected late, when the necessary interventions are profound, and the prognosis pessimistic. "Throughout the development process," says Whitehead, "we will strive to create the first test that quantifies the likelihood that an oral lesion will progress to cancer. Its modality as a minimally invasive, in-office procedure potentially means that high-risk lesions can be diagnosed earlier. The clinician, in turn, can fast-track patients who test positive for LOH onto the appropriate disease-management pathway, which will mean less invasive, less costly treatments, and more optimistic long-term prognoses. On the other hand, patients with lesions that test negative for LOH can be spared the psychological and physical trauma of unnecessary and costly interventions."

The project, titled "Development of an actionable molecular test for risk assessment of oral precancers," is funded by the Genome BC Strategic Opportunities Fund, and is designed to leverage research funded by the National Institute of Health and the Terry Fox Research Institute.

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