Photoacoustic spectroscopy can measure blood sugar noninvasively

A team of researchers from the Biophysics Institute at the University of Frankfurt in Germany has devised a novel, noninvasive spectroscopy-based approach to make blood glucose monitoring in diabetes easier. Using infrared (IR) laser light applied on top of the skin, they can measure sugar levels in the fluid in and under skin cells to read blood sugar levels.

Related: Noninvasive blood glucose measurement clears hurdle

The work could lead to a cheaper means for patients to measure their blood glucose levels without pricking and test strips, explains lead researcher Werner Mäntele, Ph.D. The optical approach uses photoacoustic spectroscopy (PAS) to measure glucose by its mid-IR absorption of light. A painless pulse of laser light applied externally to the skin is absorbed by glucose molecules and creates a measurable sound signature that enables researchers to detect glucose in skin fluids in seconds.

Related: Photoacoustic tomography is ready to revolutionize

Related: Photoacoustic device promising for routine breast cancer screening

The data showing the skin cell glucose levels at one-hundredth of a millimeter beneath the skin is related to blood glucose levels, Mäntele says, but previous attempts to use PAS in this manner have been hampered by distortion related to changes of air pressure, temperature, and humidity caused by the contact with living skin.

To overcome these constraints, the team devised a design innovation of an open, windowless cell architecture. While it is still experimental and would have to be tested and approved by regulatory agencies before becoming commercially available, the team continues to refine it.

In a close collaboration with an industry partner (Elte Sensoric; Gelnhausen, Germany), they expect to have a small shoebox-sized device ready in three years, followed by a portable glucometer some years later.

Full details of the work appear in the Review of Scientific Instruments; for more information, please visit http://scitation.aip.org/content/aip/journal/rsi/84/8/10.1063/1.4816723.

-----

Follow us on Twitter, 'like' us on Facebook, and join our group on LinkedIn

Subscribe now to BioOptics World magazine; it's free!

POST A COMMENT

Related Articles

Label-free optical biosensor can detect rotavirus

Researchers at the Universidad Politécnica de Madrid (UPM) in Spain, using a label-free optical biosensor they developed, have found a way to enhance detection capacity of small concentrations of r...
Synthetic, blue light-sensitive molecular switches can be utilized to control biochemical signaling processes in living cells

Blue LED light enables control of insulin secretion

An international team of researchers has incorporated a synthetic, blue light-sensitive molecular switch into a sulfonylurea compound—a class of drugs widely used to regulate blood glucose levels i...

Abbott, Carl Zeiss Meditec enter distribution agreement for laser cataract surgery product portfolio

Abbott Medical Optics (Santa Ana, CA) and Carl Zeiss Meditec (Jena, Germany) have entered into a nonexclusive agreement in which Abbott will offer each company's suite of laser cataract surgery pro...

Photodynamic therapy for deep cancer cells could get a boost with new nanoparticle

An international team of researchers has combined a new type of nanoparticle with an FDA-approved photodynamic therapy (PDT) to effectively kill deep-set cancer cells in vivo with minimal damage to...

BLOGS

Optogenetics among photonics techniques highlighted at Neuroscience 2014

Optogenetics among photonics techniques highlighted at Neuroscience 2014

Technology in general, and optogenetics in particular, is a focus here at Neuroscience 2015, wher...
BioOptics World editor-in-chief Barbara Goode

What is biophotonics?

At BioOptics World, our focus is photonics (including optics) for life sciences—that is, biophoto...

Nobel Prize honors super-resolution optical microscopy

"This year's prize is about how the optical microscope became a nanoscope," said Staffa...

Most Popular Articles


CONNECT WITH US

            

Twitter- BioOptics World

Copyright © 2007-2014. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS