FTIR spectroscopy helps predict bone density, fracture risk

Researchers at the University of Eastern Finland (Joensuu and Kuopio, Finland) used bone histomorphometry and Fourier transform infrared (FTIR) spectroscopy to reveal abnormal bone properties in children with vertebral fractures and in children after solid organ transplantation. Bone compositional changes in children with vertebral fractures and after different types of organ transplantation have not been reported previously.

Related: FTIR spectroscopy method characterizes Staph bacteria quickly

Related: IR spectroscopy illuminates protein structure and function

Bone samples were investigated using bone histomorphometry, a microscopic method that provides information about bone metabolism and remodeling. In children with vertebral fractures, there were changes in bone composition, such as lower carbonate-to-phosphate-ratio and increased collagen maturity (determined using FTIR spectroscopy), which could explain the increased fracture risk. The results also suggest that in children who have undergone kidney, liver, or heart transplantation, the various changes related to bone microarchitecture and turnover may be more important predictors of fracture risk than lowered bone mineral density alone. Early detection of such changes in bone quality could help prevent fractures.

Bone histomorphometry at 100x magnification
In bone histomorphometry at 100x magnification, mineralized bone tissue is recognized as green trabeculaes. Newly formed, unmineralized bone tissue, such as osteoid, is seen as red seams on top of the mineralized bone tissue. Bone marrow is located between the bone trabeculae.

Osteoporosis is the most common metabolic bone disease characterized by abnormal bone formation and resorption, which lead to increased risk of bone fractures. However, the present diagnostics based on the measurement of bone mineral density predict fractures only moderately. In addition to decreased bone mineral density, changes in bone quality could explain increased fragility related to osteoporosis. The present study confirmed that bone histomorphometry is needed in clinical practice to study remodeling balance in bone in certain patient groups.

The findings have been published in the Journal of Bone and Mineral Research and the Journal of Bone and Mineral Metabolism.

-----

Follow us on Twitter, 'like' us on Facebook, and join our group on LinkedIn

Subscribe now to BioOptics World magazine; it's free!

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

Optical sensor could assist with needle placement for epidurals, other procedures

A newly developed optical sensor can be embedded into an epidural needle, helping to guide the needle to the correct location.  

Multispectral method is noninvasive for imaging tissue oxygenation

A new multispectral approach for imaging tissue oxygenation could eliminate the need for surgical intervention.

Raman spectroscopy can help study blood stored in plastic blood bags

Raman spectroscopy can help study blood stored in plastic blood bags

Raman spectroscopy can monitor biochemical changes and inter-donor variability in stored red blood cell units.

Raman spectroscopy-based graphene sensor could detect viruses

Raman spectroscopy-based graphene sensor could detect viruses

A graphene sensor based on Raman spectroscopy can detect trace amounts of molecules, and could someday detect viruses.

BLOGS

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...

CONNECT WITH US

            

Twitter- BioOptics World