Nanoparticle tracking analysis has utility in developing future cancer solutions

Scientists at the School of Medicine and the Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) at Trinity College Dublin in Ireland are using nanoparticle tracking analysis (NTA)—a laser-based measurement technique—to develop future diagnostic and theranostic solutions for early diagnosis, drug delivery, and treatment of cancer.

Related: Laser-enabled nanoparticle quantification aids metastasis research

Related: Nanoparticle tracking analysis characterizes vaccines

Dr. Adriele Prina-Mello, a Research Fellow at CRANN and a part-time lecturer at the School of Medicine, is focusing on functional biomaterials, diagnostic devices, and multifunctional nanomaterials for theranostic solutions in the treatment of cancer. Fundamental in his work is the understanding of particle size, size distribution, and of hydrodynamic response of nanoparticles dependent on their degree of aggregation. Also, the ability to measure zeta potential and track particle behavior in viscous or physiologically relevant media addresses the demands of the nanomedicine community, where comprehensive, low-volume testing of sometimes very "expensive" samples is needed.

Adriele Prina-Mello, Kieran Staunton, and Ciaran Maguire with NanoSight's NS500 nanoparticle tracking analysis (NTA) system
Adriele Prina-Mello, Kieran Staunton, and Ciaran Maguire with NanoSight's NS500 nanoparticle tracking analysis (NTA) system. (Image courtesy of the Nanomedicine group, Trinity College Dublin)

"Our main motivation for such levels of characterization is determined by the potential use, applicability, and safety aspect linked to nanosize materials," explains Prina-Mello. "This allows for further modification of the particle surface coating/moieties in order to get closer to the suitable candidate for diagnostic, monitoring, and therapeutic application for nanomedicine and/or biomedical research and also clinical translation. Furthermore, we also need characterization information as basic preliminary understanding in order to address wider experimental screening based on pharmaceutical standards necessary to identify potential nanoparticle as lead carrier candidates for drug delivery of therapeutics."

The NTA instrumentation (the NS500 system from NanoSight [Salisbury, England]) being used in the researchers' work enables identification of heterogeneity in particle size, poly-dispersity, and counting, with simultaneous zeta potential measurement, says Prina-Mello.

-----

Follow us on Twitter, 'like' us on Facebook, and join our group on LinkedIn

Subscribe now to BioOptics World magazine; it's free!

 

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

FDA authorizes emergency use of Zika virus molecular detection assay

The xMAP MultiFLEX Zika RNA assay combines optofluidics and digital signal processing to detect Zika virus in vitro.

Merz acquires laser tattoo removal device maker ON Light Sciences

Merz North America has acquired ON Light Sciences, which develops technologies to enhance laser-based dermatology procedures.

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.

Laser therapy extracts rare tumor that grew human hair, skin in boy's skull

About four years ago, a tumor comprised of human skin, hair, bone and cartilage was fast-growing inside a Ramsey, MN, 10-year-old youth's brain.
BLOGS

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...

CONNECT WITH US

            

Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS