OCT plays important part in new quantitative imaging biomarker for scleroderma

Scientists at the Institute of Rheumatic and Musculoskeletal Medicine at the University of Leeds in England, using an optical coherence tomography (OCT) scanner, have developed the first quantitative imaging biomarker for skin involvement in scleroderma (a chronic autoimmune disorder that affects the skin and one or more internal organs).

Related: OCT technique for assessing scleroderma wins Abbot Innovation Award

To develop their quantitative model, the research team—led by Francesco Del Galdo, MD, Ph.D.—performed 458 OCT scans on 21 scleroderma patients (1 morphea and 22 healthy controls), comparing the results with clinical assessment and histology.

The OCT scanner the research team used (Michelson Diagnostics' VivoSight) enabled noninvasive imaging 1–2 mm beneath the surface of the skin with unprecedented detail. It also allowed them to evaluate images captured of the dermal-epidermal junction and dermis using specially designed image processing algorithms. The significant correlation of the optical density with skin thickness and the excellent inter and intraobserver reliability of the technique suggests that an OCT-based algorithm is an accurate and reliable tool to quantify skin involvement in scleroderma.

"Our study is the first in the field proposing a quantitative imaging biomarker of skin fibrosis in scleroderma," explains Giuseppina Abignano, MD, lead author of the study. "We are currently undertaking a longitudinal study to test the sensitivity of the OCT-based algorithm. These studies will tell us whether we can use OCT to determine changes in skin fibrosis over time and therefore use it as outcome measure in clinical trials and in clinical management. This is a very important step toward improving the prognosis for people who suffer from this devastating disease."

The research team's results appear in Annals of the Rheumatic Diseases; for more information, please visit http://ard.bmj.com/content/early/2013/02/19/annrheumdis-2012-202682.


Follow us on Twitter, 'like' us on Facebook, and join our group on LinkedIn

Subscribe now to BioOptics World magazine; it's free!

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

Eye test that pairs two in vivo imaging methods may detect Parkinson's earlier

A low-cost, noninvasive eye test pairs two in vivo imaging methods to help detect Parkinson's before clinical symptoms appear.

Lightweight handheld probe for OCT provides insight into children's retinas

A handheld device is capable of capturing OCT images of a retina with cellular resolution in infants and toddlers.

Optical brain imaging noninvasively measures small perfusion changes caused by visual stimulation

An optical brain imaging system can track very small, focal changes in cortical perfusion resulting from visual stimulation.

Optical Coherence Tomography: Beyond better clinical care: OCT's economic impact

The optical coherence tomography (OCT) industry has grown dramatically in its first 25 years.


Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS