Consortium forms to tackle artificial tissue generation

Under the leadership of the Fraunhofer Institute for Laser Technology (ILT; Aachen, Germany), a consortium of 16 European partners from industry and the research community are tackling artificial tissue generation for implants. One of the biggest challenges in medical research has been to create multi-layer tissue structures designed to enable the diffusion of nutrients for surrounding cells in a similar manner to natural tissue.

On November 23 and 24, 2011, Fraunhofer ILT held the kick-off meeting for the ArtiVasc 3D project, which will receive €7.8 million of funding from the European Commission under the Seventh Framework Programme. On the project, a team of engineers, scientists, and medical experts will develop a new process of engineering a vascularized scaffold for artificial tissue. In other words, they plan to provide the tissue with a blood supply similar to that of natural arteries. Using current technologies, skin grafts that do not require vascularization cannot be grown beyond a surface area of 1 cm2 and a thickness of 1–2 mm. For larger and thicker areas of tissue, vascularization is necessary.

The ArtiVasc 3D project team at the Fraunhofer Institute for Laser Technology ILT in Aachen
The ArtiVasc 3D project team at the Fraunhofer Institute for Laser Technology ILT in Aachen. (Image courtesy of Fraunhofer ILT)

Over the next four years, the consortium will combine different technologies from the fields of additive manufacturing and biofunctionalization to develop a process capable of engineering blood vessels in an artificial scaffold system. These vascularized scaffolds will be populated with autologous cells in order to enable the formation of vascularized fatty tissue and, ultimately, artificial skin. This artificial skin will be used as an in-vitro test system—for example, to reduce the number of animal experiments—and employed directly in skin grafts.

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