TILL Photonics two-photon digital microscope for in-vivo imaging

The two-photon iMIC digital microscope from TILL Photonics (Graefelfing, Germany) for in-vivo imaging features a two-photon laser scanning platform and a voice coil-based focus drive to enable 3-D scans. Additional features include digital galvo control, flexible line speeds from 40 μs to several seconds, two channels for epifluorescence and two channels for transmission fluorescence observation, and fixed 4 MHz sampling speed with variable oversampling.



Two Photon iMIC Digital Microscope

Superb Resolution and Highest Flexibility

TILL Photonics proudly introduces the Two-Photon iMIC digital microscope. When it comes to fluorescence imaging of thick tissue, two-photon excitation microscopy is the new gold standard for in-vivo imaging.

The Two-Photon iMIC combines two major advantages for researchers in a fast and accurate, but still flexible way.

Increased penetration depth will enable researchers to see more deeply into samples. Up until now this capability was out of reach.

Reducing tissue damage while probing deeper enhances further research. The iMIC give the researcher the capability to do enhanced live-cell imaging.

The combination of increased depth and damage reduction opens new areas of research.

The iMIC-based two-photon laser scanning platform in combination with
the novel voice coil-based focus drive enables 3-D scans of unprecedented volume and accuracy.

Colibri LaserScan Software
The Colibri LaserScan open source software offers full control over the basic setup, including the motorized microscope and the scan head and also provides the flexibility of including further components, such as cameras, into the system.

Key Features of Two-Photon iMIC:

  • Digital galvo control
  • Pixel time <1μs; flexible line speeds from 40μs to several s.
  • Speed based scan description
  • Up to 4 channels: 2 for epi-fluorescence and 2 for transmission fluorescence observation
  • Bidirectional scanning with all speeds
  • Arbitrary scan tracks
  • Spot scan
  • Fixed 4 MHz sampling speed with variable oversampling
  • Line scan


Posted by Lee Mather

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