Microscopy technique yields color maps of tumor margins

Nonlinear interferometric vibrational imaging (NIVI) is a novel microscopy technique that delivers easy-to-read, color-coded images of tissue that outline clear tumor boundaries, which could eliminate the wait for cancer biopsy results. The study in mouse models of breast cancer showed that the new technology was more than 99% accurate and delivered results in minutes, as reported by the journal Cancer Research in its December 1 issue.

The NIVI technology, developed by Stephen Boppart and colleagues from the Beckman Institute for Advanced Science and Technology at the University of Illinois (Urbana, IL), is based on the concept that pathologic anomalies are associated with variations in the biochemical composition of cells, and that different molecules have distinctive vibrational energy states in their bonds. The rationale for use of NIVI imaging in oncology lies in the fact that cancer cells have a higher concentration of proteins, whereas healthy cells have a higher concentration of lipids.

NIVI uses two beams of light—one for a reference and the other to excite the tissue and isolate the signal. The resulting image analysis yields red for cancer and blue for healthy cells, allowing for a color map of the tumor margins.

In the current paper, the investigators showed that in a rat model of breast cancer, the technology could differentiate between cancer and normal tissue sections with greater than 99% confidence intervals and define cancer boundaries to ±100 µm with greater than 99% confidence interval using fresh, unstained tissue sections. Imaging results were available in less than five minutes.

The investigators are currently working to make the approach faster, the equipment more compact and even portable, with the ultimate goal of developing new light delivery systems, such as catheters, probes or needles that can test tissue in situ without the need to remove samples.

Source: Cancer Research


Posted by Lee Mather

Follow us on Twitter

Subscribe now to BioOptics World magazine; it's free!

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

FDA authorizes emergency use of Zika virus molecular detection assay

The xMAP MultiFLEX Zika RNA assay combines optofluidics and digital signal processing to detect Zika virus in vitro.

Merz acquires laser tattoo removal device maker ON Light Sciences

Merz North America has acquired ON Light Sciences, which develops technologies to enhance laser-based dermatology procedures.

Shortwave-infrared device could improve ear infection diagnosis

An otoscope-like device that could improve ear infection diagnosis uses shortwave-infrared light instead of visible light.

Laser therapy extracts rare tumor that grew human hair, skin in boy's skull

About four years ago, a tumor comprised of human skin, hair, bone and cartilage was fast-growing inside a Ramsey, MN, 10-year-old youth's brain.

Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World

Copyright © 2007-2016. PennWell Corporation, Tulsa, OK. All Rights Reserved.PRIVACY POLICY | TERMS AND CONDITIONS