TILL Photonics imaging workstation uses a single spinning disk

The iMIC-Andromeda imaging workstation from TILL Photonics (Graefelfing, Germany) can perform total internal reflection fluorescence (TIRF), fluorescence recovery after photobleaching (FRAP), photoactivation, fluorescence resonance energy transfer (FRET), fluorescence correlation spectroscopy (FCS), multi-photon, structured illumination, and proprietary confocal laser spinning disk imaging applications. Instead of using microlenses and two synchronized rotating disks, the Andromeda uses a single spinning disk and places long-pass dichroics into the infinity space, improving point spread function (PSF) and providing higher resolution and optical sectioning.



TILL Photonics Introduces iMIC – Andromeda

TILL's iMIC-Andromeda is an imaging workstation capable of combining a broad range of imaging applications. The modular approach of the iMIC allows the integration of methods such as TIRF, FRAP, Photoactivation, FRET, FCS, Multiphoton, Structured Illumination and last but not least our proprietary Laser Spinning Disk Confocal Andromeda.

The heart of the Andromeda is a single spinning disk which derives its outstanding performance and versatility from its fundamentally new optical concept. Instead of using microlenses and two synchronized rotating disks, Andromeda needs only a single disk and places (long-pass) dichroics where they belong, into the infinity space. This greatly improves the point spread function (PSF) and provides higher resolution and better optical sectioning than achieved by previous approaches.


How can a single disk perform a function that other approaches need two disks for? The core component of Andromeda features a novel patented optical design, quasi-hexagonal pattern of concave micro-mirrors, carrying pinholes in their center. While the micro-mirrors form a rotating point pattern, a retro-reflector projects the focus pattern back onto the pinholes where it can pass and reach the sample.

This elegant approach ensures maximal optical throughput and enables a much better matching to the numerical aperture (NA) of a variety of objectives, including water immersion—and low magnification objectives.

Key features of iMIC - Andromeda

  • Modular concept for more configurations
  • Automation to control complex experiments
  • Flexible software for changing demands
  • Integration of all major fluorescence techniques possible
    • Epifluorescence and TIRF
    • FRAP and Photoactivation
    • FRET, FCS, Multiphoton
    • Structured Illumination
  • Laser Spinning Disk Confocal (Andromeda)
    • Improved smoothness of rotation (all units run at 10.000 rpm)
    • Field optimized for 9x9mm CCD chips, bigger fields (sCMOS) in preparation.
    • Full automation of all filters (10 excitation-filters, 10 emission-filters and 5 dichroics)


Posted by Lee Mather

Follow us on Twitter

Subscribe now to BioOptics World magazine; it's free!

Get All the BioOptics World News Delivered to Your Inbox

Subscribe to BioOptics World Magazine or email newsletter today at no cost and receive the latest news and information.

 Subscribe Now
Related Articles

New bioimaging technique offers clear view of nervous system

Scientists at Ludwig-Maximilians University have developed a technique for turning the body of a deceased rodent entirely transparent, revealing the central nervous system in unprecedented clarity....

Fluorescent jellyfish proteins light up unconventional laser

Safer lasers to map your cells could soon be in the offing -- all thanks to the humble jellyfish. Conventional lasers, like the pointer you might use to entertain your cat, produce light by emittin...

Fluorescence microscopy helps provide new insight into how cancer cells metastasize

By using fluorescence microscopy, scientists have discovered an alternate theory on how some cancer cells metastasize.

In vivo imaging method visualizes bone-resorbing cell function in real time

In vivo imaging can visualize sites where osteoclasts (bone-resorbing cells) were in the process of resorbing bone.


Neuro15 exhibitors meet exacting demands: Part 2

Increasingly, neuroscientists are working with researchers in disciplines such as chemistry and p...

Why be free?

A successful career contributed to keeping OpticalRayTracer—an optical design software program—fr...

LASER Munich 2015 is bio-bent

LASER World of Photonics 2015 included the European Conferences on Biomedical Optics among its si...

White Papers

Understanding Optical Filters

Optical filters can be used to attenuate or enhance an image, transmit or reflect specific wavele...

How can I find the right digital camera for my microscopy application?

Nowadays, image processing is found in a wide range of optical microscopy applications. Examples ...



Twitter- BioOptics World