Study shows UV light can cut spread of TB by 70% in hospitals

MARCH 17, 2009--A study published today in PLoS Medicine reports that ultraviolet (UV) lights could reduce the spread of tuberculosis in hospital wards and waiting rooms by 70%. The study explored the transmission of tuberculosis (TB) from infected patients to guinea pigs; it suggests that installing simple ultraviolet C (UVC) lights in hospitals could help reduce transmission of even drug-resistant strains of TB. The light kills TB bacteria by damaging their DNA so they cannot grow, divide, or infect people. It is already used at high intensity to disinfect empty ambulances and operating theatres.

TB bacteria can be killed by hanging a shielded UVC light from the ceiling with a fan to mix the air, say the researchers, from Imperial College London, the University of Leeds, Hospital Nacional Dos de Mayo, Lima, Perú and other international institutions. Dr. Rod Escombe, the study's principal investigator from the Wellcome Trust Centre for Clinical Tropical Medicine at Imperial College London, said: "When people are crowded together in a hospital waiting room, it may take just one cough to infect several vulnerable patients. Our previous research showed that opening windows in a room is a simple way to reduce the risk of tuberculosis transmission, but this is climate-dependent--you can't open the windows in the intensive care ward of a Siberian hospital for example."

"Thankfully, the rate of tuberculosis infection in countries like the UK is relatively low and people who are infected can be treated using antibiotics, which are readily available here. People are more likely to die from the disease in developing countries like Perú, because there are limited resources for isolating patients, diagnosing them quickly and starting effective treatment. Also, the prevalence of drug-resistant TB is much higher in the developing world. Preventing infection is much easier and cheaper than treating a patient with tuberculosis," added Escombe.

Plans are already underway to install upper room UV lights in the chest clinic at St Mary's Hospital, part of the Imperial College Healthcare NHS Trust, which will be the first hospital to have them in the UK.

Introducing UVC lights could be a relatively low-cost measure, say the researchers. Currently, a typical UVC ceiling light costs around $350 and replacement bulbs cost from $25. The researchers are now working to develop more affordable $100 units.

The impact of UV lights is greatest when combined with careful management of the air flow on the wards, as Dr. Cath Noakes from the University of Leeds' Faculty of Engineering explains: "The lights must be set high enough to ensure patients and health workers are not overexposed, but if the lights only treat air at that level, there will be little benefit. To be most effective, ventilation systems need to create a constant flow of treated air down to patient level, and potentially infected air up towards the lights."

To reach their conclusions, scientists hung UVC lights in a hospital ward in Lima, Perú where 69 patients with HIV and TB were being treated. The researchers pumped air from the ward up to a guinea pig enclosure on the roof of the hospital for 535 consecutive days. The guinea pigs were split into three groups of approximately 150: the first group received air exposed to the UV lights in the ward, the second group received ward air treated with negative ionisers, and the third control group was given untreated air straight from the ward. The guinea pigs were given skin tests for tuberculosis once a month.

By the end of the experiment, 35% of the control group were infected with TB, compared to 14% of the ionised air group and 9.5% of the UVC group. 8.6% of the control group developed the active form of the disease after being infected with TB, compared to 4.3% of the ionised air group and 3.6% of the UVC group.

This research was funded by the Wellcome Trust, Sir Halley Stewart Trust and the Sir Samuel Scott of Yews Trust, Proyecto Vigia (USAID) and the charity Innovation for Health and Development (IFHAD).

More information:
See the paper, Upper-Room Ultraviolet Light and Negative Air Ionization to Prevent Tuberculosis Transmission in PLoS Medicine.

Posted by Barbara G. Goode, barbarag@pennwell.com, for BioOptics World.

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